This is my second marriage. The first one ended with divorce because I could not have children with my ex-husband. I am Rh-negative. Two of our kids died, one at three days and one at two and a half years. My second husband is Rh-positive, and I am afraid of getting pregnant again. We had a blood test done, and they told us that I have a 90 percent chance of Rh-positive kids with my husband, so the chance to have an Rh-negative child is very small, but it is still possible. Is there a way to take my eggs and his sperm, then to fertilize my eggs and determine which one is Rh-negative and use that one for pregnancy?

Olga

I assume that your previous children died from complications of RH hemolytic disease and you are sensitized against the Rh antigen. I am not aware of any option to test embryos for Rh status, and I do not believe that present-day prenatal genetic diagnosis would make this feasible.

While amniocentesis can be used to monitor the pregnancy and determine whether the fetus would benefit from an intrauterine transfusion, I think you would do well to consider use of an RH-negative sperm donor to avoid this condition.