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Fibrates are a type of cholesterol-reducing drug. These medications lower the levels of fats (lipids) in the blood, including cholesterol and triglycerides. They also are effective in raising high density lipoprotein (HDL), or “good” cholesterol, in the blood.

There are three types of fibrates currently on the market in the United States. Fibrates are generally well tolerated by most people. Gastrointestinal problems are the most common complaints among people taking fibrates. These types of drugs can affect other prescription and over-the-counter medications, particularly anticoagulants. Patients need to inform their physician and pharmacist of all medicines they are taking to avoid interactions.

Other types of cholesterol-reducing drugs include statins, bile acid resins and nicotinic acid. All are commonly used to treat high cholesterol, but fibrates are most effective at lowering triglyceride levels. These also somewhat raise HDL cholesterol levels.

High levels of cholesterol, triglycerides and other fats in the bloodstream increase the risk of hardening of the arteries (atherosclerosis), heart attack, stroke and other heart-related conditions. Fibrates, in conjunction with lifestyle changes, have been shown to reduce the risk of these heart conditions.